Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Buchheit, KM., Soahil, A., Hacker, J., Maurer, R., Gakpo, D., Bensko, JC., Taliaferro, F., Ordovas-Montanes, J., Laidlaw, TM. Immunity
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2021
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
Huang, S., Ziegler, C.G.K., Austin, J., Mannoun, N., Vukovic, M., Ordovas-Montanes, J., Shalek, A.K., von Andrian, U.H. Cell
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Cyclin D3 drives intertial cell cycling in dark zone germinal center B cells
Pae, J., Ersching, J., Castro, TBR, Schips, M., Mesin, L., Allon, SJ., Ordovas-Montanes, J., Mlynarczyk, C., Melnick, A., Efeyan, A., Shalek, AK., Meyer-Hermann, M., Victora, G. Journal of Experimental Medicine-PDF
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Bein, A.*, Kim, S.*, Goyal, G.*, Cao, W.*, Fadel, C.*, Naziripour, A., Sharma, S., Swenor, B., LoGrande, N., Nurani, A., Miao, V. N., Navia, A. W., Ziegler, C., Ordovas-Montanes, J., Prabhala, P., Kim, MS., Prantil-Baun, R., Rodas, M., Jiang, A., O'Sullivan, L., Tillya, G., Shalek, AK., Ingber, DE.
* Co-main authors
Cell-PDF
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Tkachev, V.#, Kaminski. J., Potter, EL., Furlan, SN., Yu, A., Hunt, DJ., McGuckin, C., Zheng, H., Colonna, L., Gerdemann, U., Carlson, J., Hoffman, M., Olvera, J., English, C., Baldessari, A., Panoskaltsis-Mortari, A., Watkins, B., Qayed, M., Suessmuth, Y., Betz, K., Bratrude, B., Langston, A., Horan, JT., Ordovas-Montanes, J., Shalek, AK., Blazar, BR., Roederer, M., Kean, LS.#
# Co-corresponding authors
Science Translational Medicine-PDF
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
Buchheit, KM., Lewis, E., Gakpo, D., Hacker, J., Sohail, A., Taliaferro, F., Giron, EB., Asare, C., Vukovic, M., Bensko, JC., Dwyer, DF., Shalek, AK., Ordovas-Montanes, J., Laidlaw, TM. Journal of Allergy and Clinical Immunology
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Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Ziegler, CGK.*, Miao, VN.*, Owings, AH.*, Navia, AW.*, Tang, Y.*, Bromley, JD., Lotfy, P., Sloan, M., Laird, H., Williams, HB., George, M., Drake, RS., Christian, T., Parker, A., Sindel, CS., Burger, MW., Pride, Y., Hasan, M., Abraham III, GE., Senitko, M., Robinson, TO., Shalek, A.K.#, Glover, SC.#, Horwitz, BH.#, Ordovas-Montanes, J.#
* Co-main authors, # Co-corresponding authors Cell
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Prior upregulation of interferon pathways in the
nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children
Costa-Martins, AG., Mane, K., Lindsey, BB., Ogava, RL., Castro, Í., Jagne, YJ., Sallah, HJ., Armitage, EP., Jarju, S., Ahadzie, B., Ellis-Watson, R., Tregoning, JS., Bingle, CD., Bogaert, D., Clarke, E., Ordovas-Montanes, J., Jeffries, D., Kampmann, B., Nakaya, HI., de Silva, TI. Cell Reports Medicine
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Desmosterol suppresses macrophage inflammasome
activation and protects against vascular
inflammation and atherosclerosis
Zhang, X., McDonald, JG., Aryal, B., Canfran‐Duque, A., Goldberg, EL., Araldi, E., Ding, W., Fan, Y., Thompson, BM., Singh, AK. Li, Q.,Tellides, G., Ordovas-Montanes, J., Garcia Milian, R., Deep Dixit, V., Ikonen, E., Suarez, Y., Fernandez-Hernando, C. Proceedings of the National Academy of Sciences
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Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation
Ouahed, J.*, Kelsen, JR.*, Spessott, WA., Kooshesh, K., Sanmillan, ML., Dawany, N., Sullivan, KE., Hamilton, KE., Slowik, V., Nejentsev, S., Neves, JF., Flores, H., Chung, WK., Wilson, A., Anyane-Yeboa, K., Wou, K., Jain, P., Field, M., Tollefson, S., Dent, MH., Li, D., Naito, T., McGovern, DPB., Kwong, AC., Taliaferro, F., Ordovas-Montanes, J., Horwitz, BH., Kotlarz, D., Klein, C., Evans, J., Dorsey, J., Warner, N., Elkadri, A., Muise, AM., Goldsmith, J., Thompson, B., Engelhardt, KR., Cant, AJ., Hambleton, S., Barclay, A., Toth-Petroczy, A., Vuzman, D., Carmichael, N., Bodea, C., Cassa, CA., Devoto, M., Maas, RL., Behrens, EM., Giraudo, CG., Snapper, SB.
* Co-main authors Journal of Crohn's and Colitis
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2020
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies