Publications - Ordovas-Montanes Lab

Publications

Preprints

2022

2021

2020

2019

2018 and Earlier

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults
Cao, Y., Guo, Z., Vangala, P., Donnard, E., Liu, P., McDonel, P., Ordovas-Montanes, J., Shalek, A.K., Finberg, R.W., Wang, J.P., Garber, M.
* Co-main authors
bioRxiv

Are we there yet? An immune field trip through human embryonic development
Niederlova, V., Kazer, SW., Ordovas-Montanes, J.
Immunity - PDF

Role of Respiratory Epithelial Cells in Allergic Diseases
Jakwerth, CA., Ordovas-Montanes, J., Blank, S., Schmidt-Weber, CB., Zissler, UM.
Cells - PDF

Robust differentiation of human enteroendocrine cells from intestinal stem cells
Zeve, D., Stas, E., de Sousa Casal, J., Mannam, P., Qi, W., Yin, X., Dubois, S., Shah, MS., Syverson, EP., Hafner, S., Karp, JM., Carlone, DL, Ordovas-Montanes, J., Breault, DT.
Nature Communications - PDF

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Mead, BE., Hattori, K., Levy, L., Imada, S., Goto, N., Vukovic, M., Sze, D., Kummerlowe, C., Matute, JD., Duan, J, Langer, R., Blumberg, RS., Ordovas-Montanes, J., Yilmaz, OH., Karp, JM., Shalek, AK.
Nature Biomedical Engineering - PDF

Rapid and sustained effect of dupilumab on clinical and mechanistic outcomes in aspirin-exacerbated respiratory disease
Buchheit, KM., Soahil, A., Hacker, J., Maurer, R., Gakpo, D., Bensko, JC., Taliaferro, F., Ordovas-Montanes, J., Laidlaw, TM.
Journal of Allergy and Clinical Immunology - PDF

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Buchheit, KM., Soahil, A., Hacker, J., Maurer, R., Gakpo, D., Bensko, JC., Taliaferro, F., Ordovas-Montanes, J., Laidlaw, TM.
Immunity - PDF

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
Huang, S., Ziegler, C.G.K., Austin, J., Mannoun, N., Vukovic, M., Ordovas-Montanes, J., Shalek, A.K., von Andrian, U.H.
Cell - PDF

Cyclin D3 drives intertial cell cycling in dark zone germinal center B cells
Pae, J., Ersching, J., Castro, TBR, Schips, M., Mesin, L., Allon, SJ., Ordovas-Montanes, J., Mlynarczyk, C., Melnick, A., Efeyan, A., Shalek, AK., Meyer-Hermann, M., Victora, G.
Journal of Experimental Medicine - PDF

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Bein, A., Kim, S., Goyal, G., Cao, W., Fadel, C., Naziripour, A., Sharma, S., Swenor, B., LoGrande, N., Nurani, A., Miao, V. N., Navia, A. W., Ziegler, C., Ordovas-Montanes, J., Prabhala, P., Kim, MS., Prantil-Baun, R., Rodas, M., Jiang, A., O'Sullivan, L., Tillya, G., Shalek, AK., Ingber, DE.
Co-main authors
Cell - PDF

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Tkachev, V.#, Kaminski. J., Potter, EL., Furlan, SN., Yu, A., Hunt, DJ., McGuckin, C., Zheng, H., Colonna, L., Gerdemann, U., Carlson, J., Hoffman, M., Olvera, J., English, C., Baldessari, A., Panoskaltsis-Mortari, A., Watkins, B., Qayed, M., Suessmuth, Y., Betz, K., Bratrude, B., Langston, A., Horan, JT., Ordovas-Montanes, J., Shalek, AK., Blazar, BR., Roederer, M., Kean, LS.#
# Co-corresponding authors
Science Translational Medicine - PDF

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Dwyer, DF., Ordovas-Montanes, J., Allon, SJ., Buchheit, KM., Vukovic, M., Derakhshan, T., Feng, C., Lai, J., Hughes, TK., Nyquist, SK., Giannetti, MP., Berger, B., Bhattacharyya, N., Roditi, RE., Katz, HR., Nawijn, MC., Berg, M., Van Den Berge, M., Laidlaw, TM., Shalek, AK.#, Barrett, NA.#, Boyce, JA.#
* Co-main authors, # Co-corresponding authors
Science Immunology - PDF

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
Buchheit, KM., Lewis, E., Gakpo, D., Hacker, J., Sohail, A., Taliaferro, F., Giron, EB., Asare, C., Vukovic, M., Bensko, JC., Dwyer, DF., Shalek, AK., Ordovas-Montanes, J., Laidlaw, TM.
Journal of Allergy and Clinical Immunology - PDF

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Ziegler, CGK., Miao, VN., Owings, AH., Navia, AW., Tang, Y., Bromley, JD., Lotfy, P., Sloan, M., Laird, H., Williams, HB., George, M., Drake, RS., Christian, T., Parker, A., Sindel, CS., Burger, MW., Pride, Y., Hasan, M., Abraham III, GE., Senitko, M., Robinson, TO., Shalek, A.K.#, Glover, SC.#, Horwitz, BH.#, Ordovas-Montanes, J.#
Co-main authors, # Co-corresponding authors
Cell - PDF

Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children
Costa-Martins, AG., Mane, K., Lindsey, BB., Ogava, RL., Castro, Í., Jagne, YJ., Sallah, HJ., Armitage, EP., Jarju, S., Ahadzie, B., Ellis-Watson, R., Tregoning, JS., Bingle, CD., Bogaert, D., Clarke, E., Ordovas-Montanes, J., Jeffries, D., Kampmann, B., Nakaya, HI., de Silva, TI.
Cell Reports Medicine - PDF

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
Zhang, X., McDonald, JG., Aryal, B., Canfran‐Duque, A., Goldberg, EL., Araldi, E., Ding, W., Fan, Y., Thompson, BM., Singh, AK. Li, Q.,Tellides, G., Ordovas-Montanes, J., Garcia Milian, R., Deep Dixit, V., Ikonen, E., Suarez, Y., Fernandez-Hernando, C.
Proceedings of the National Academy of Sciences - PDF

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation
Ouahed, J., Kelsen, JR., Spessott, WA., Kooshesh, K., Sanmillan, ML., Dawany, N., Sullivan, KE., Hamilton, KE., Slowik, V., Nejentsev, S., Neves, JF., Flores, H., Chung, WK., Wilson, A., Anyane-Yeboa, K., Wou, K., Jain, P., Field, M., Tollefson, S., Dent, MH., Li, D., Naito, T., McGovern, DPB., Kwong, AC., Taliaferro, F., Ordovas-Montanes, J., Horwitz, BH., Kotlarz, D., Klein, C., Evans, J., Dorsey, J., Warner, N., Elkadri, A., Muise, AM., Goldsmith, J., Thompson, B., Engelhardt, KR., Cant, AJ., Hambleton, S., Barclay, A., Toth-Petroczy, A., Vuzman, D., Carmichael, N., Bodea, C., Cassa, CA., Devoto, M., Maas, RL., Behrens, EM., Giraudo, CG., Snapper, SB.
* Co-main authors
Journal of Crohn's and Colitis - PDF

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
Hughes, TK., Wadsworth, MH., Gierahn, TM., Do, T., Weiss, D., Andrade P.R., Ma, F., de Andrade Silva, BJ., Shao, S., Tsoi, LC., Ordovas-Montanes, J., Gudjonsson, JE., Modlin, RL., Love, JC.^#, Shalek, AK.^#
Co-main authors, ^ Co-senior authors, # Co-corresponding authors
bioRxiv - Immunity - PDF

Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease
Mitsialis V., Wall S., Liu P., Ordovas-Montanes, J., Parmet, T., Vukovic, M., Spencer, D., Field, M., McCourt, C., Tthaker, J., Bousvaros, A., BCH IBD Center, BWH Crohn’s and Colitis Center, Shalek. A., Kean, L., Horwitz, B., Goldsmith, J., Tseng, G., Snapper, S.B.^#, Konnikova, L^#.
^ Co-senior authors, # Co-corresponding authors
Gastroenterology - PDF

SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
Ziegler, C.G.K., Allon, S.J., Nyquist, S.K., Mbano, I.M., Miao, V.N., Tzouanas, C.N., Cao, Y., Yousif, A.S., Bals, J., Hauser, B.M., Feldman, J., Muus, C., Wadsworth II, M.H., Kazer, S.W., Hughes, T.K., Doran, B., Gatter, G.J., Vukovic, M., Taliaferro, F., Mead, B.E., Guo, Z., Wang, J.P., Gras, D., Plaisant, M., Ansari, M., Angelidis, I., Adler, H., Sucre, J.M.S., Taylor, C.J., Lin, B., Waghray, A., Mitsialis, V., Dwyer, D.F., Buchheit, K.M., Boyce, J.A., Barrett, N.A., Laidlaw, T.M., Carroll, S.L., Colonna, L., Tkachev, V., Peterson, C.W., Yu, A., Zheng, H.B., Gideon, H.P., Winchell, C.G., Lin, P.L., Bingle, C.D., Snapper, S.B., Kropski, J.A., Theis, F.J., Schiller, H.B., Zaragosi, L.-E., Barbry, P., Leslie, A., Kiem, H.-P., Flynn, J.L., Fortune, S.M., Berger, B., Finberg, R.W., Kean, L.S., Garber, M., Schmidt, A.G., Lingwood, D., Shalek, A.K.#, Ordovas-Montanes, J.#, HCA Lung Biological Network
* Co-main authors, # Co-corresponding authors
Cell - PDF

Distribution and Storage of Inflammatory Memory in Barrier Tissue
Ordovas-Montanes, J., Beyaz, S., Rakoff-Nahoum S., Shalek, A.K.
Nature Reviews Immunology - PDF

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Kazer, SW., Aicher, TP., Muema, DM., Carroll, SL., Ordovas-Montanes, J., Miao, VN., Tu, AA., Ziegler, CGK., Nyquist, SK., Wong, EB., Ismail, N., Moodly, A., Berger, B., Love, JC., Dong, K., Leslie, A., Ndhlovu, ZM., Ndung’u T., Walker, BD., Shalek, AK.
bioRxiv - Nature Medicine - PDF

IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease
Buchheit, KM., Dwyer, DF., Ordovas-Montanes, J., Katz, H., Lewis, E., Vukovic, M., Lai, J., Bankova, L., Bhattacharyya, N., Shalek, AK., Barrett, NA., Boyce, JA., Laidlaw, TM.
bioRxiv - Journal of Allergy and Clinical Immunology - PDF

Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
Smillie, CS., Biton, M., Ordovas-Montanes, J., Sullivan, K., Burgin, G., Graham, DB., Herbst, RH., Rogel, N., Slyper, M., Waldman, J., Sud, M., Andrews, EA., Haber, AL., Vickovic, S., Dionne, D., Nguyen, LT., Villani, AC., Hofree, M., Creasey, EA., Huang, H., Rozenblatt-Rosen, O., Garber, JJ., Khalili, H., Desch, AN., Daly, MJ., Ananthakrishnan, AN.#, Shalek, AK.#, Xavier, RJ.#, Regev, A.#.
Co-main authors, # Co-corresponding authors
bioRxiv - Cell - PDF

Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Pepe-Mooney, BJ., Dill, MT., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M, Anakk, S., Dawson, PA., Ono, N., Shalek, AK., van Oudenaarden, A., Camargo, FD.#
* Co-main authors, # Corresponding author
Cell Stem Cell - PDF

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
Biton, M., Haber, AL., Beyaz, S., Rogel, N., Smillie, C., Shekhar, K., Chen, Z., Wu, C., Ordovas-Montanes, J., Alvarez, D., Herbst, RH., Tirosh, I., Burgin, G., Dionne, D., Zhang, M., Rozenblatt-Rosen, O., Shi, HN., Kuchroo, V., Yilmaz, O., Regev, A.^, Xavier, RJ.#
* Co-main authors, ^ Senior author, # Corresponding author
bioRxiv - Cell - PDF

Allergic inflammatory memory in human respiratory epithelial progenitor cells
Ordovas-Montanes, J., Dwyer, DF., Nyquist, SK., Buchheit, KM., Vukovic, M., Deb, C., Wadsworth, MH., Hughes, TK., Kazer, SW., Yoshimoto, E., Bhattacharyya, N., Cahill, KN., Katz, HR., Laidlaw, TM., Boyce, JA., Barrett, NA#. Shalek, AK#.
* Co-main authors, # Co-corresponding authors
bioRxiv - Nature - PDF

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Mead, BE.#, Ordovas-Montanes, J., Braun, AP., Levy, L., Szucs, MJ, MacMullan, M., Ammendolia, D., Zheng, Y., Bhargava, P., Yin, X., Hughes, TK., Wadsworth III, MH., Ahmad, R., Rakoff-Nahoum, S., Carr, S., Langer, R., Collins JJ., Shalek, AK., Karp, JM.#
* Co-main authors, # Co-corresponding authors
BMC Biology - PDF

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
Martin-Gayo, E., Cole, M., Kolb, KE., Ouyang, Z., Cronin, J., Kazer, SW., Ordovas-Montanes, J., Lichterfeld, M., Walker, BD., Yosef, N.#, Shalek, AK.#, Yu, XG.#
# Co-corresponding authors
Genome Biology - PDF

Novel in vitro booster vaccination to rapidly generate antigen-specific fully human monoclonal antibodies from healthy individuals
Nandin, IS., Fong, C., Deantonio, C., Torreno-Pina, JA., Pecetta, S., Maldonado, P., Gasparrini, F., Ordovas-Montanes, J., Kazer, SW., Kjaer, S., Borley, DW., Nair, U., Coleman, JA., Lingwood, D., Shalek, AK., Meffre, E., Poignard, P., Burton, DR., Batista, FD.#
* Co-main authors, # Corresponding author
Journal of Experimental Medicine - PDF

The Whiteboard Revolution: Illuminating Science Communication in the Digital Age
Mar, FA., Ordovas-Montanes, J., Oksenberg, N., Olson, AM.
Trends in Immunology - PDF

The regulation of immunological processes by peripheral neurons in homeostasis and disease
Ordovas-Montanes, J., Rakoff-Nahoum, S., Huang, S., Riol-Blanco, L., Barreiro, O., von Andrian, UH.
Trends in Immunology - PDF

Nociceptive sensory neurons drive interleukin-23 mediated psoriasiform skin inflammation.
Riol-Blanco, L., Ordovas-Montanes, J., Perro, M., Naval, E., Thiriot, A., Paust, S., Wood, JN., von Andrian, UH.
* Co-main authors
Nature - PDF

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
Lafaille, FG., Pessach, IM., Zhang, SY., Ciancanelli, M., Herman, M., Mostoslavsky, G., Ordovas-Montanes, J., Jouanguy, E., Plancoulaine, S., Tu, E., Elkabetz, Y., Schlaeger, TM., Daley, GQ., Tardieu, M., Abel, L., Casanova, JL., Studer, L., Notarangelo, LD.
Nature - PDF

Cholesterol, Inflammasomes, and Atherogenesis
Ordovas-Montanes, J., Ordovas, JM.
Current Cardiovascular Risk Reports - PDF

Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies
Pessach, IM., Ordovas-Montanes, J., Zhang, SY., Casanova, JL., Giliani, S., Genery, AR., Al-Herz, W., Manos, PD., Schlaeger, TM., Park, IH., Rucci, F., Agarwal, S., Mostoslavsky, G., Daley, GQ., Notarangelo, LD.
Journal of Allergy and Clinical Immunology - PDF

Ordovas-Montanes Lab
Division of Gastroenterology, Hepatology, and Nutrition
Boston Children's Hospital
300 Longwood Avenue
Boston, MA 02115

Get in touch!
jose.ordovas-montanes at childrens.harvard.edu

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