News

Study Describing ACE2 as an Interferon-Stimulated Gene Out in Cell
April 21, 2020
Our study showing ACE2, the entry receptor for SARS-CoV-2, as an interferon-stimulated gene is now out in Cell here. Datasets analyzed in this study are described here and can be downloaded from our single-cell portal here. We hope these data prove invaluable in the global fight against the COVID-19 pandemic.

Pre-print on ACE2 as an Interferon-Stimulated Gene available now on bioRxiv
March 18, 2020
Our pre-print work detailing ACE2 upregulation in response to interferons, and type I interferons in particular, is now available here. Descriptions of the datasets analyzed in the study as well as the data can be found on our COVID-19 Resource page.

COVID-19 resources, data now available under Resources
March 14, 2020
In light of the spread of SARS-CoV-2, we are sharing multiple scRNA-seq datasets across both health and disease that harbor cells expressing ACE2 (the gene encoding the host receptor) and TMPRSS2 (the gene involved in processing the viral spike protein). We are sharing these resources for SARS-CoV-2 on the Alexandria Project. This is a project focused on enabling the community to explore single-cell data of relevance to infectious disease. An overview and introduction to the datasets can be found on our website here. We hope these data will be a useful resource for the community. We thank our colleagues for their willingness to share unpublished data, the study participants and donors, and the clinicians and scientists alike on the front lines of this pandemic.

The lab's first review is out!
February 3, 2020
The lab's first review is out now in Nature Reviews Immunology, titled "Distribution and storage of inflammatory memory in barrier tissue". We discuss what that means in terms of factors like cell state, cell lineage, and environmental exposure. Take a look here!
Thanks to our co-authors from the Rakoff-Nahoum and Shalek labs for helping us see this review to the finish line!