Studying how inflammation drives memory formation in human barrier tissues
Our research
Understanding the principles of how inflammation drives memory formation in human barrier tissues in order to program and re-program them in human disease
We are developing an interdisciplinary training environment composed of immunologists, engineers, computational biologists, and others that harnesses emerging techniques to answer fundamental questions of biological and clinical relevance in barrier tissue biology. We use a variety of techniques such as single-cell RNA-sequencing (scRNA-seq), organoid models, epigenetic profiling, flow cytometry, and microscopy in an effort to answer pressing questions surrounding human health and disease. The fundamental questions we try to answer through our work in the lab are:
Which cellular compartments harbor memories of inflammation in tissue, and how might we develop effective mechanisms by which to promote or erase them? In short, where are health and disease stored in a tissue?
Our team
Jose Ordovas-Montanes (PI)
Sam Kazer
Amanda Hornick
Peter Lotfy
Joshua De Sousa Casal
Andrew Kwong
Kyle Kimler
Faith Taliaferro
Martin Axegard
We are located in the Enders Building of Boston Children’s Hospital in the Longwood Medical Area. We’re always looking to grow our team!
Study Describing ACE2 as an Interferon-Stimulated Gene Out in Cell
April 21, 2020
Peter, Andrew, and Josh join the lab!
September 2020
Peter, Andrew, and Josh have officially joined our lab for their PhDs. We are so excited (and lucky) to have them!
Jose is named a NYSCF - Robertson Investigator!
October 20, 2020
The New York Stem Cell Foundation (NYSCF) has announced its 2020 class of NYSCF - Robertson Investigators, and Jose is one of them! This award provides our lab critical funding over five years, allowing us to carry out our work. Way to go, Jose! Read more about the award here